{"product_id":"pt-141","title":"PT-141","description":"\u003cp data-start=\"245\" data-end=\"321\"\u003ePT‑141 (Bremelanotide) is a cyclic peptide analog of α‑MSH engineered to selectively activate melanocortin receptors—MC3R and MC4R—primarily within the central nervous system. Early preclinical research demonstrated that PT‑141 induces sexual arousal mechanisms in animal models, including penile erections in rats via central receptor activation and increased c‑Fos expression in hypothalamic neurons (Molinoff et al., 2003) \u003cspan data-state=\"closed\"\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/12851303\/?utm_source=chatgpt.com\" rel=\"noopener\" target=\"_blank\"\u003eResearchGate+6PubMed+6Oxford Academic+6\u003c\/a\u003e\u003c\/span\u003e.\u003c\/p\u003e\n\u003cp data-start=\"323\" data-end=\"437\"\u003eIn rodent behavioral assays, PT‑141 triggered elevated proceptive sexual behaviors and restored mating performance in pain-modulated models, suggesting central modulation of sexual motivation pathways \u003cspan data-state=\"closed\"\u003e\u003ca href=\"https:\/\/www.researchgate.net\/publication\/5886434_Bremelanotide_An_Overview_of_Preclinical_CNS_Effects_on_Female_Sexual_Function?utm_source=chatgpt.com\" rel=\"noopener\" target=\"_blank\"\u003eResearchGate\u003c\/a\u003e\u003c\/span\u003e. Unlike traditional vasodilatory-based peptides, PT‑141 operates through central neurotransmitter modulation.\u003c\/p\u003e\n\u003cp data-start=\"439\" data-end=\"555\"\u003eHuman clinical trials further examined PT‑141's efficacy. In the RECONNECT phase III trials, subcutaneous administration significantly increased sexual desire and decreased associated distress in premenopausal women with hypoactive sexual desire disorder, demonstrating statistical significance and favorable tolerability profiles \u003cspan data-state=\"closed\"\u003e\u003ca href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6819021\/?utm_source=chatgpt.com\" rel=\"noopener\" target=\"_blank\"\u003eWikipedia+15PMC+15PMC+15\u003c\/a\u003e\u003c\/span\u003e. These findings support PT‑141 as a functional melanocortinergic agent influencing CNS-mediated sexual response.\u003c\/p\u003e\n\u003cp data-start=\"557\" data-end=\"637\"\u003eMechanistically, PT‑141 is proposed to elevate dopamine levels in the medial preoptic area of the hypothalamus, a key center for sexual arousal. By activating MC4R pathways, it may enhance libido and central motivational states in both male and female contexts (Clin Res \u0026amp; reviews) \u003cspan data-state=\"closed\"\u003e\u003ca href=\"https:\/\/www.mensreproductivehealth.com\/post\/pt-141-for-men-a-new-drug-to-treat-erectile-dysfunction-and-low-libido?utm_source=chatgpt.com\" rel=\"noopener\" target=\"_blank\"\u003eMen's Reproductive Health+1DrugBank+1\u003c\/a\u003e\u003c\/span\u003e.\u003c\/p\u003e\n\u003cp data-start=\"639\" data-end=\"719\"\u003ePharmacokinetic evaluations in healthy subjects and individuals with mild-to-moderate erectile dysfunction have demonstrated dose-dependent effects on erection duration, showing increased rigidity and onset latency without significant systemic blood pressure or hormonal side effects (Molinoff PB et al., 2004) \u003cspan data-state=\"closed\"\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/12851303\/?utm_source=chatgpt.com\" rel=\"noopener\" target=\"_blank\"\u003eWJMH+2PubMed+2northamptonintegrativemedicine.com+2\u003c\/a\u003e\u003c\/span\u003e.\u003c\/p\u003e\n\u003cp data-start=\"721\" data-end=\"760\"\u003eTogether, this body of work models PT‑141 as a centrally acting melanocortin receptor agonist with effects on sexual motivation and neuroendocrine signaling. Studies emphasize its ability to induce central arousal responses through peptide-based receptor modulation, distinguishing it from peripherally acting agents. Continued research explores its impact across CNS-driven behaviors and neuropeptide pathways.\u003c\/p\u003e","brand":"Chroma23® Peptides","offers":[{"title":"10mg","offer_id":47008782909675,"sku":"PT1-41-C23","price":126.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0791\/1332\/2731\/files\/PT1-Chroma-VIal.jpg?v=1765930441","url":"https:\/\/www.chroma23peptides.com\/products\/pt-141","provider":"Chroma23® Peptides","version":"1.0","type":"link"}